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The Deadliest Twister in U.S. History The weather forecast for much of the Midwest on March 18, 1925, predicted "Wind and rain." This prediction was right, but lethally inadequate. Around 1 p.m., a tornado touched down near Ellington, Missouri, and charged relentlessly for three and a half hours across Missouri, Illinois, and Indiana. The destructive storm left schools and workplaces leveled, over 600 dead and 1,600 injured in its two-hundred-nineteen-mile wake--earning it the name, the Great American Tornado. A nation united, doctors and nurses rushed aboard express trains. The Red Cross orchestrated an enduring six-month relief campaign, and people contributed funds and condolences from around the world. Amidst the staggering ruin, volunteers, the Red Cross, and ordinary heroes like Isaac Levy spearheaded awe-inspiring recovery efforts that rivaled the powerful storm.